New optically active metoprolol tartrate salts, and method of preparing them, and method of preparing optically active metoprolol from the tartrate salts.

摘要

This invention relates to new optically active metoprolol tartrate salts, (2S)-1-isopropylamino-3-[p-(2-methoxyethyl)phenoxy]-2-propanol-(2S min , 3S min )-O,O-di-p-toluoyltartrate salts (formula 1), and (2R)-1-isopropylamino-3-[p-(2-methoxyethyl)phenoxy]-2-propanol-(2R min , 3R min )-O,O-di-p-toluoyltartrate salts (formula 2), and preparation thereof and of optically active metoprolol from the tartrate salts which is caracterized in that optically active substances of metoprolol, which function as cures for essential hypertension, angina pectoris, and tachycardiac arhythmia can be provided readily and industrially. <CHEM> <CHEM> t