| 发明名称 |
CELL STRESS TRANSCRIPTIONAL FACTORS |
| 摘要 |
The present invention relates to DNA sequence coding for part or all of the heat shock transcription factor or heat shock factor (HSF) proteins derived from humans and Drosophila, and the proteins encoded by these sequences. The present invention also includes methods for detecting HSF in a biological sample. The presence of HSF in the nucleus of a colt can be detected with specific anti-HSF antibody reagents. The presence of such HSF proteins in th e nucleus indicates a stressed condition including diseases. Furthermore, the presence of multimeric HSF in the crude ar fractionated cell extract is indicative of a stressed state.
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| 申请公布号 |
CA2096975(A1) |
申请公布日期 |
1992.05.27 |
| 申请号 |
CA19912096975 |
申请日期 |
1991.11.22 |
| 申请人 |
UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, U.S. DEPARTMENT OF COMMERCE (THE) |
发明人 |
WU, CARL;CLOS, JOACHIM;WESTWOOD, TIMOTHY J.;RABINDRAN, SRIDHAR |
| 分类号 |
A61K39/395;C07K7/06;C07K7/08;C07K14/00;C07K14/435;C07K14/47;C07K16/00;C07K16/18;C07K19/00;C12N1/21;C12N15/09;C12N15/67;C12P21/02;C12P21/08;C12Q1/68;C12R1/19;G01N33/53;G01N33/577;(IPC1-7):C12N15/12;G01N33/566;C12N15/62 |
主分类号 |
A61K39/395 |
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