发明名称 |
PROTECTIVE FOUR AMINO ACID EPITOPE AGAINST PLASMODIUM VIVAX MALARIA |
摘要 |
A synthetic peptide of the human malaria Plasmodium vivax, containing at least one repeat of a synthetic peptide having the amino acid sequence Ala-Gly-Asp-Arg (AGDR) which is a protective epitope found on the circumsporozoite (CS) protein of the sporozoites of the human maleria Plasmodium vivax. When a monoclonal antibody specific for this four amino acid sequence binds to the CS protein of the P. vivax sporozoite in vivo, infection is prevented. Also described are pharmaceutical formulations of these peptides. |
申请公布号 |
AU9125791(A) |
申请公布日期 |
1992.05.26 |
申请号 |
AU19910091257 |
申请日期 |
1991.11.01 |
申请人 |
UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE |
发明人 |
STEPHEN L HOFFMAN;YUPIN CHAROENVIT;TREVOR R JONES |
分类号 |
A61K39/00;C07K5/103;C07K14/445 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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