发明名称 |
BIGUANIDES AND DERIVATIVES THEREOF AS INHIBITORS OF ADVANCED GLYCOSYLATION OF A TARGET PROTEIN |
摘要 |
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. |
申请公布号 |
AU9021791(A) |
申请公布日期 |
1992.05.26 |
申请号 |
AU19910090217 |
申请日期 |
1991.10.25 |
申请人 |
THE ROCKEFELLER UNIVERSITY |
发明人 |
PETER C. ULRICH;ANTHONY CERAMI |
分类号 |
A61K8/43;A61K31/155;A61K31/40;A61K31/44;A61K31/445;A61K31/495;A61K31/535;A61K31/55;A61Q11/00;A61Q19/08;C07K16/28;G01N33/573 |
主分类号 |
A61K8/43 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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