发明名称 |
PEPTIDES AND ANTIBODIES THAT INHIBIT PLATELET ADHESION |
摘要 |
A polypeptide analog capable of immunologically mimicking a linear hGPIIb antigenic determinant expressed when platelet-associated GPIIb-IIIa binds fibrinogen is disclosed. An antibody that immunoreacts with the polypeptide and hGPIIb when hGPIIb is present as a platelet-associated GPPIb-IIIa/fibrinogen complex is also disclosed. Further disclosed are diagnostic systems and methods for assaying fibrinogen-bound platelets in a vascular fluid sample using the polypeptides and/or antibodies of the invention.
|
申请公布号 |
US5114842(A) |
申请公布日期 |
1992.05.19 |
申请号 |
US19880175342 |
申请日期 |
1988.03.31 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
PLOW, EDWARD F.;GINSBERG, MARK H. |
分类号 |
G01N33/50;A61K38/00;A61K39/395;A61K49/00;A61P7/02;C07K14/00;C07K14/47;C07K14/705;C07K14/745;C07K16/00;C07K16/18;C07K16/28;C07K16/36;C12N5/10;C12N15/02;C12N15/09;C12P21/08;C12R1/91;G01N33/15;G01N33/53;G01N33/566;G01N33/569;G01N33/577 |
主分类号 |
G01N33/50 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|