摘要 |
The invention relates to a method for production of optically active (+)-bicyclo-¢3.3.0!-octanol derivatives of formula (+)-I, (+)-I, where R1 and R2 together imply an oxygen atom or the bivalent radical -O-X-O- where X is a straight-chain or branchedchain alkylene group with 1 - 7 C-atoms or R1 and R2 in each case imply the radical -OR5 with R5 as a straight or branched-chain alkyl group with 1 - 7-C atoms and R3 the radical COOZ with Z as a hydrogen atom, a straight or branched-chain alkyl group with 1 to 7 C-atoms, a cycloalkyl group with 3 to 6 C-atoms, a phenyl group or an aralkyl group with 7 to 10 C-atoms, or R3 implies the radical -(CH2)n-O-COR4 with n having the significance 1 - 4 and R4 being a straight or branched-chain alkyl group with 1 to 7 C-atoms, a cycloalkyl group with 3 to 6 C-atoms, a phenyl group or an aralkyl group with 7 to 10 C-atoms, characterised in that racemic 3.alpha.-acyloxy-cis-bicyclo- ¢3.3.0!-octane derivatives of the formula (?)-II (?)-II, where R1, R2, R3, and R4 have the above significance, are subjected, enzymatically or microbiologically, to stereospecific acylate hydrolysis and the resultant (+)-bicyclo- ¢3.3.0!-octanol derivative (+)-I is separated from the nonsaponified bicyclo-¢3.3.0!-octanol-acylate of formula (-)-II or the non-saponified enantiomer (+)-II is separated from the saponified bicyclo-¢3.3.0!-octanol derivative (-)-I and then subjected to chemical acylate hydrolysis. |