| 摘要 |
PROCESS FOR PREPARING 2-DEOXYNUCLEOSIDES An O-, S-, or N-silyl- or O-, S-, or N-alkyl-pyrimidine is reacted with a protected 1-halo-, 1-alkoxy-, or 1-acyloxy-2- deoxy sugar in the presence of cuprous iodide and a halohydrocarbon solvent to prepare a nucleoside having an improved beta-anomer/alpha-anomer ratio. In a preferred embodiment of the invention, 2,4-bis(tri-methylsilyloxy)-5-methylpyrimidine or 2,4-bis(trimethyl-silyloxy)-5-ethylpyrimidine is reacted with 2-deoxy-3,5-di-O-p-toluyl-D-erythro-ribofuranosyl chloride in the presence of cuprous iodide and chloroform. |
