4(3H)-OXO-5,6,7,8-TETRAHYDROPYRIDO(2,3-D)PYRIMIDINE DERIVATIVES

摘要

960-104/106 OUS 4(3H)-OXO-5,6,7,8-TETRAHYDROPYRIDO- ¢2,3-D!PYRIMIDINE DERIVATIVES Derivatives of N-¢4-(N-¢2-amino-4(3H)-oxo-5,6,7,8-tetrahydropyrido¢2,3-d!pyrimidin-6-ylmethyl-amino)benzoyl! L-glutamic acid are antineoplastic agents which can be prepared by hydrolysis of the corresponding compounds in which the 2-amino group and the glutamic acid carboxylic acid groups are protected.