| 摘要 |
The present invention is concerned with compounds of formula 1 <CHEM> wherein RO is alkyl, alkoxy or alkylthio having 1-4 carbon atoms, hydroxy, halogen, Z, together with the carbon atom and the nitrogen atom and the intermediate carbon atom, constitutes a heterocyclic group which consists of 5-8 ring atoms, in which, besides the already present nitrogen atom, a second hetero atom from the group N, O, or S may be present, which ring may be substituted with 1-4 methyl groups or which ring may be annelated with a phenyl group optionally substituted with fluorine, or a methyl or methoxy group; A is a group of formula 2 or 3 <CHEM> wherein one of the groups R3, R4 and R5 is hydrogen, alkyl having 1-6 carbon atoms, cycloalkyl having 3-7 carbon atoms, alkenyl having 2-6 carbon atoms or phenyl alkyl having 1-3 carbon atoms in the alkyl group, and the two other groups independently of each other are hydrogen or alkyl having 1-4 carbon atoms, or wherein A is a polycyclic ring system in which one carbon atom is replaced by a tertiary nitrogen atom, for example, a ring system of formula 4, 5 or 6, <CHEM> wherein p is an integer having the value 1 or 2, q is an integer having the value 2, 3 or 4, r is an integer having the value 1, 2 or 3, and R6 is alkyl having 1-4 carbon atoms, cycloalkyl having 3-6 carbon atoms, cyclopropylmethyl, allyl, propargyl or benzyl, and B is an oxygen atom or a group =N-R, wherein R is hydrogen, alkyl having 1-6 carbon atoms or benzyl, or wherein B-A represents a group of formula 7 <CHEM> wherein R3 and R5 have the meanings defined above, and the pharmaceutically acceptable acid addition salts thereof, which are pharmaceutically active as 5-HT receptor antagonists, and pharmaceutical products containing these compounds. e |
