BIGUANIDES AND DERIVATIVES THEREOF AS INHIBITORS OF ADVANCED GLYCOSYLATION OF A TARGET PROTEIN

摘要

The present invention relates to methods and compositions for inhibiting nonenzymatic cross-linking (protein aging). The compositions comprise biguanide derivatives which are capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The methods comprise contacting the target proteins with the composition. Various therapeutic applications to treat protein aging are provided, as well as uses in dentistry (teeth staining) and food spoilage.