PROSTAGLANDIN ANALOG, COMPOUND, ITS PREPARATION, AND DRUG COMPOSITION COMPRISING IT

摘要

NEW MATERIAL:A compound shown by the formula I (R<1> is 1-4C alkyl; R<2> is single bond or 1-5C alkylene; R<3> is H, 1-8C alkyl, alkoxy, 4-7C cycloalkyl, etc.; R<4> is H or OH-protecting groups; X is ethylene or cis-cinylene; Y is group shown by the formula II or III; the double bonds of the two position are both transforms; waveline is alpha-configuration, beta-configuration, etc.). EXAMPLE:(2E, 5Z, 13E)-(9alpha-11alpha, 15R)-N-Methanesulfonyl-9-hydroxyl-11, 15- bis (tetrahydropyran-2-yloxy)-16- (4-chlorophenoxy)-17, 18, 19, 20-tetranorprosta- 2, 5, 13-triene-1-amide. USE:A drug for remedying hypertension, thrombosis, etc. and effective for delivery induction, abortion, etc. PROCESS:The -R<6>-R<7> of a compound shown by the formula IV (R<5> is OH removable under acidic conditions; R<6> is S, etc.; R<7> is 1-4C alkyl, etc.) is subjected to oxidative releasing reaction to give a compound shown by the formula I wherein Y is a group shown by the formula II and R<4> is R<5>.