BIOLOGICAL ACTIVE MATERIAL COVALENTLY IMMOBILIZED ON TO AZLACTONE-FUNCTIONAL POLYMERIC SUPPORTS AND METHOD FOR PREPARING IT

摘要

Biologically active material covalently immobilized to azlactone-functional polymeric supports in the presence of polyanionic salt and azlactone quencher is provided. The biologically active material is immobilized rapidly and achieves both high density and optimized bound specific biological activity. A method to prepare such biologically active adduct supports is also provided using a highly ionic salt solution also optionally containing azlactone quencher which unexpectedly enhances bound specific biological activity.