ALLERGENS OF ALDER POLLEN AND APPLICATIONS THEREOF

摘要

PCT No. PCT/EP91/01479 Sec. 371 Date Jun. 1, 1992 Sec. 102(e) Date Jun. 1, 1992 PCT Filed Aug. 6, 1991 PCT Pub. No. WO92/02621 PCT Pub. Date Feb. 20, 1992This invention provides recombinant DNA molecules which code for polypeptides that exhibit the antigenicity of an Aln g I allergen of alder, Alnus sp., of a Cor a I allergen of hazel or of a Bet v I allergen of birch and other plants of the order Fageles, and for polypeptides comprising at least one epitope thereof, as well as nucleic acids which under stringent conditions hybridize with such DNA sequences or are derivable from such sequences by degeneracy of the genetic code. In addition, methods are described for using the polypeptides coded by these DNA molecules and their use in the diagnosis or therapy of allergic diseases.