| 发明名称 |
N-PHENYL PIPERIDINYLCAMPHORSULFONYL OXYTOCIN ANTAGONISTS |
| 摘要 |
95/FPG53 96/FPG54 97/FPG55 98/FPG56 -i- 18241IA TITLE OF THE INVENTION PIPERIDINYLCAMPHORSULFONYL OXYTOCIN ANTAGONISTS Spirocyclic compounds of the formula: I 95/FPG53 - ii - 18241IA The compounds of formula I are oxytocin and vasopressin antagonists useful in the treatment of preterm labor, dysmenorrhea and for the stoppage of labor preparatory to cesarean delivery, timing of parturition, uterine hyperactivity, endometriosis, hypertension, congestive heart failure, hyponatremia and cognitive disorders. Also disclosed are pharmaceutical compositions containing these compounds, methods of their use and methods of their preparation.
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| 申请公布号 |
CA2055024(A1) |
申请公布日期 |
1992.05.14 |
| 申请号 |
CA19912055024 |
申请日期 |
1991.11.06 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
BOCK, MARK G.;EVANS, BEN E.;FREIDINGER, ROGER M.;GILBERT, KEVIN;HOBBS, DOUG W.;LUNDELL, GEORGE F.;PETTIBONE, DOUGLAS J.;RITTLE, KENNETH E. |
| 分类号 |
A61K31/435;A61K31/50;A61K31/55;A61K31/675;A61P13/02;A61P15/00;C07D221/20;C07D401/12;C07D405/12;C07D409/12;C07D413/12;C07D417/12;C07D417/14;C07D419/12;C07F9/576;C07K5/02;(IPC1-7):C07D221/20;A61K31/445;A61K31/54 |
主分类号 |
A61K31/435 |
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