Esters and amides of substituted fused ring phenyl acetic acids.

摘要

Esters and amides of substituted fused ring phenyl acetic acids having the formula <CHEM> wherein Y, together with the ring to which it is fused forms a multi-ring system selected from napthyl, [1]benzopyranol [2, 3-b], pyridine, phenothiazine, carbazole, and benzoxazole; R1 is lower alkyl or hydrogen; R2 is one or more independently selected from cyano, nitro, amino, alkylamino, hydrogen, halogen, lower alkyl, lower alkoxy, hydroxy, phenyl or phenyl substituted with halogen, alkyl or alkoxy; wherein Q is the deprotonated residue of a polymer or macromolecular structure having a molecular weight of at least 1000 containing at least two primary and/or secondary amino groups and/or hydroxy groups; and n is an integer of at least 2 are useful in treating colonic polyps.