Process for the preparation of 3-alkoxymethyl cephalosporin derivatives.

摘要

A compound of formula (I): <CHEM> or a salt thereof, is prepared by reacting 7-amino-cephalosporanic acid or a salt thereof, with a solution comprising a compound of formula ROSO3H in a compound of formula ROH, and in the presence of at least one compound of formula B(OR)3 or compound of formula CH2(OR)2; in which, in each of said compounds of formulae (I), ROSO3H, ROH, B(OR)3 and CH2(OR)2, R represents an alkyl group having from 1 to 6 carbon atoms.