摘要 |
<p>A medicament for preventing and treating circulatory organ diseases contains as an effective ingredient a spiro-3-heterozolidine compound represented by the following formula: <CHEM> wherein R<1> and R<2>, which may be identical or different, each represent a hydrogen atom, an alkyl group, a pyrrolizidinoalkyl group, a group -(CH2CH2O)nCH3 in which n represents an integer of 1 to 113 or a substituted or unsubstituted phenyl group or alternatively R<1> and R<2> may form, together with the nitrogen atom to which they are bonded, a substituted or unsubstituted heterocyclic group, optionally containing a further nitrogen or oxygen atom; T represents a sulfur atom, or a nitrogen atom which may be bonded to a hydrogen atom, U represents an oxygen or sulfur atom, or an imino group; X represents an oxygen or sulfur atom; and Y and Z, which may be identical or different, each represent a hydrogen or halogen atom or an alkyl, alkoxy or alkylmercapto group; or a pharmacologically acceptable salt or solvate thereof.</p> |
申请人 |
SANWA KAGAKU KENKYUSHO CO., LTD. |
发明人 |
KURONO, MASAYASU, SANWA KAGAKU, KENKYUSHO CO.,LTD.;MIURA, KENJI, SANWA KAGAKU, KENKYUSHO CO.,LTD.;KONDO, YASUAKI, SANWA KAGAKU, KENKYUSHO CO.,LTD.;USUI, TOSHINAO, SANWA KAGAKU, KENKYUSHO CO.,LTD.;HAYASHI, MOTOHIDE, SANWA KAGAKU, KENKYUSHO CO.,LTD;SUZUKI, TUNEMASA, SANWA KAGAKU, KENKYUSHO CO.,LTD;TOMIYA, NOBORU, SANWA KAGAKU, KENKYUSHO CO.,LTD;NAKAMURA, SHIGEYOSHI, SANWA KAGAKU, KENKYUSHO CO.;TANAKA, YUKIYA, SANWA KAGAKU, KENKYUSHO CO., LTD.;SAWAI, KIICHI, SANWA KAGAKU, KENKYUSHO CO., LTD. |