NEW PEPTIDE, ITS PRODUCTION AND USE THEREOF

摘要

NEW MATERIAL:A peptide of formula Phe-Gln-Pro. USE:A low toxic angiotensinase inhibitor useful as a preventive and therapeutic agent of hypertension, an antihypertensive agent, a therapeutic agent of congestive cardiac failure, etc., with high safety. PREPARATION:A protein (preferably fish protein such as dried bonito or actin) is initially mixed with (hot) water and the resultant mixture is homogenized. Thermolysin is then added thereto followed by hydrolysis at 10-85 deg.C for 0.1-48hr. The resultant hydrolyzed solution is concentrated by centrifugal separation and subsequently purified by high performance liquid chromatography, etc.