The use of lipoxygenase and cyclooxygenase inhibitors as synergistic agents.

摘要

The invention relates to synergistic agents for the treatment of inflammatory or arthritic conditions which comprise one of a selected group of inhibitors of the enzyme 5-lipoxygenase in conjunction or admixture with an inhibitor of the enzyme cyclooxygenase. Conveniently the 5-lipoxygenase inhibitor is, for example, 6-[(3-fluoro-5-[4-methoxy-3,4,5,6-tetrahydro-2H-pyran-4-yl]phenoxy)met hyl]-1-methyl-2-quinolone or 4-[5-fluoro-3-(4-methyl-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-7-ylthio)p henyl]-4-methoxytetrahydropyran and the cyclooxygenase inhibitor is selected from indomethacin, flurbiprofen and diclofenac. The invention also relates to a pharmaceutical composition containing said synergistic agent and to the use of said agent in the manufacture of a medicament for the synergistic treatment of inflammatory or arthritic disease.