| 发明名称 |
RADIOLABELED PROTEINS FOR DIAGNOSTIC OR THERAPEUTIC USE |
| 摘要 |
Chelating compounds of specified structure are useful for radiolabeling targeting molecules such as antibodies. Cleavable linkers connect the radionuclide metal chelates to the antibodies. The radiolabeled antibodies have improved biodistribution properties, including reduced localization within the intestines and kidneys.
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| 申请公布号 |
US5112953(A) |
申请公布日期 |
1992.05.12 |
| 申请号 |
US19890457480 |
申请日期 |
1989.12.29 |
| 申请人 |
NEORX CORPORATION |
发明人 |
GUSTAVSON, LINDA M.;SRINIVASAN, ANANTHACHARI;KASINA, SUDHAKAR;RENO, JOHN M.;FITZNER, JEFFREY N.;JONES, DAVID S. |
| 分类号 |
A61K51/00;A61K38/00;A61K47/48;A61K51/10;A61P35/00;C07D207/46;C07D309/08;C07K1/107;C07K5/06;C07K5/08;C07K5/083;C07K14/00;C07K14/52;C07K14/575;C07K16/00;C09K3/00;G01N33/534;G01N33/577 |
主分类号 |
A61K51/00 |
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