HYBRID CELLS PRODUCING AN ANTIGEN CHARACTERISTIC OF THE HEPATITIS B VIRUS OBTAINED FROM HEPATOCYTES AND ESTABLISHED MONKEY CELLS, A PROCESS FOR OBTAINING THESE HYBRID CELLS AND THEIR APPLICATION TO THE PRODUCTION OF THE AFORESAID ANTIGEN

摘要

PCT No. PCT/FR86/00147 Sec. 371 Date Feb. 19, 1987 Sec. 102(e) Date Feb. 19, 1987 PCT Filed Apr. 29, 1986.The invention concerns hybrid cells transformed or transformable by a cloned DNA containing the sequence coding for the antigen HBs. They are characterized in that they contain, on the one hand, at least a part of the genetic heritage of monkey hepatocyte cells and, on the other hand, a genetic marker permitting them to grow in a selective medium or one containing an active principle normally lethal to the VERO cells from which the hybrid is derived, but able to be inactivated by the polypeptide expressed by the said genetic marker.