| 摘要 |
1306472 Maleic anhydride/vinyl ether copolymers; proteinic compositions MERCK PATENT GmbH 19 April 1971 [26 Feb 1970] 22503/71 Headings C3C C3H and C3P A water-soluble but readily meltable crosslinked copolymer of maleic anhydride and at least one vinyl ether is prepared by copolymerzing maleic anhydride with at least one vinyl ether, the ratio of maleic anhydride to vinyl groups being approximately 1 : 1 and at least 5% of the vinyl groups originating from a divinyl ether. A substance containing reactive groups may be covalently bonded to the copolymer by reacting the substance with the copolymer, the ratio of copolymer to the substance being 5 : 1 to 1 : 5. In the examples maleic anhydride, butane-1,4-diol divinyl ether, hexane- 1,6-diol divinyl ether, ethyl vinyl ether and diethylene glycol divinyl ether, are copolymerized in the presence of dibenzoyl peroxide, benzene, azoisobutyronitrile, butyl acetate, toluene, glycerol mono-oleate, heptane, azoisobutyrodinitrile, acetonitrile, naphtha benzine, formamide, n-octane, sorbitol mono-oleate and petroleum ether. The resulting copolymers are reacted with papaine, pig's trypsin, ribonuclease, piperidine, lysine hydrochloride, phenol, nbutanol, 2 - mercaptoethanol, adenosine - 5<SP>1</SP>- monophosphoric acid, thiophenol, oestradiol, hexamethylene diamine, pyridoxamine dihydrochloride and p-aminophenyl mercuriacetate. Porous polymers are produced in Examples 12 to 16. |
