PROCESS FOR PREPARING BENZO[C]PHENANTHRIDINIUM DERIVATIVES, AND NOVEL COMPOUNDS PREPARED BY SAID PROCESS

摘要

The present invention relates to a process for preparing benzo¢c!phenanthridinium derivatives of the general formula A: (A) wherein M and N individually represent a hydroxyl or lower alkoxy group, or M and N simultaneously represent a hydrogen atom or together form a methylenedioxy group, X- represents an acid residue or a hydrogen acid residue, and R represents a lower alkyl group. This process has good reproducibility and may be effected under moderate conditions, and therefore the process is practically useful. Also, it has been found that certain novel benzo¢c!phenanthridinium derivatives, prepared by the present process, have not only an antitumor activity but also an inhibition activity on blood platelet aggregation. In addition, hydrogen salts of the present compounds have an enhanced stability, which is an advantage in formulating into phamaceutical preparations.