PHARMAZEUTISCHER STOFF FUER DIE BEHANDLUNG VON MYELOGENER LEUKAEMIE.

摘要

Agent for the treatment of myelogenous leukemia contains a human granulocyte colony stimulating factor (hGCSF) as effective ingredient. Pref. the hG-CSF has : mol. wt. 19,000 +/-; 0.1, 5.8 +/- 0.1, 6.1+/-0.1; UVmax 280 nm, UVmin 250 nm; and N-terminal Z1 amino acid sequence: H2N-Thr-Pro-Leu-Gly-Pro-Ala- Ser-Ser-Leu-Pro-Gln-Ser-Phe-Leu-Leu-Lys-Cys-Leu-Glu- Gln-Val- . A full amino acid sequence is also claimed for a further pref. hG-CSF. Type (A) hG-CSF may be prepd.by the methods of EP applications 85109336.9 and 86113671.1 Type (B) hG-CSF may be pred. as in EP 86901138.7. All methods are recombinant DNA technology.