发明名称 Process for the preparation of N-alkylated quaternary nitrogen containing aromatic heterocycles
摘要 The synthesis of 4-, 4-(1,1)-and 3,5-substituted N-alkyl-pyridinium salts as well as of 2-carboxamide substituted N(1,4)diazinium compounds are described. The N-surfactants obtained have a small critical micelle concentration (CMC) of 10-5 -10-7 Mol/Liter. These surfactants produce micells of different size and form depending on the nature of the anions. 4-(1,1)-substituted and 3,5-substituted N-alkyl-pyridinium components are capable of forming vesicles in equeous solutions of different forms and sizes. The N-surfactants synthesized can be used as pharmaceuticals.
申请公布号 US5110929(A) 申请公布日期 1992.05.05
申请号 US19900538350 申请日期 1990.06.14
申请人 MEDICE CHAM.-PHARM. FABRIK PUTTER GMBH & CO. KG 发明人 PARADIES, HENRICH H.
分类号 A61K9/107;A61K47/18;C07D213/20;C07D213/30;C07D213/63;C07D213/65;C07D213/68;C07D213/69;C07D213/73;C07D213/80;C07D213/81;C07D213/82;C07D235/06;C07D239/26;C07D239/30;C07D239/46;C07D239/47;C07D239/54;C07D239/553;C07D241/24;C07D277/22;C07D277/62;C07D473/04;C07D473/16;C07D487/04;C07D521/00 主分类号 A61K9/107
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