发明名称 PURIFICATION OF IL-2-CONTAINING HYBRID COMPOUNDS
摘要 A method for purifying from a mixture of hybrid compound which contains a portion of IL-2, which portion includes at least a region of the IL-2R binding domain of IL-2, which region is effective to cause the hybrid compound to bind to cells containing an IL-2R. The method includes passing the mixture containing the hybrid compound over a column having attached thereto molecules consisting of or containing a complex sugar moiety with affinity for the hybrid compound, and eluting the hybrid compound with a suitable eluant. The invention also features related complexes of the hybrid compound and assays for the hybrid compound.
申请公布号 US5110912(A) 申请公布日期 1992.05.05
申请号 US19900487604 申请日期 1990.03.02
申请人 SERAGEN, INC. 发明人 ESTIS, LEONARD F.
分类号 A61K38/00;A61P37/06;C07K1/16;C07K1/22;C07K14/00;C07K14/195;C07K14/52;C07K14/54;C07K14/55;C07K14/76;C07K19/00;G01N30/88;G01N33/68 主分类号 A61K38/00
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