Benzene sulphonylureas

摘要

1. Cpds. - (I) where X = phthalimido (opt. hydrogd., mono- or di-substd. by lower alkyl, alkoxy, halogen), tetrahydro- or hexahydro-endomethylene-phtha limido, tetrahydro or hexahydro-endoethylenephthalimido, napththalimido, naphthalene 1,2- or 2,3- dicarbonimido. - Y = alkylene (1-4 carbons, pref. ethylene), opt. branched - R' = (one or more of) H, halogen, lower alkyl or alkoxy (1-4 carbons) (N.B. phenylene nucleus pref. para). - R = alkyl, alkenyl, or S-alkyl (all 2-8 carbons); alkoxyalkyl or alkyl-S-alkyl (both 4-8 carbons (is not 2 carbons for alkylene portion)); lower phenylalkyl, phenylcyclopropyl; lower cyclo-hexylalkyl, cycloheptyl-methyl or ethyl, cyclo-octylmethyl; endoalkylene-cyclohexyl, or-cyclo-hexenyl, or-cyclohexylmethyl, or-cyclohexenyl-methyl (all with 1-2 endoalkylene carbons); lower alkyl-or alkoxy-cyclohexyl; cycloalkyl (5-8 carbons); cyclohexenyl, cyclohexenyl-methyl; heterocyclic (opt. linked to N by -CH2-) (4-5 carbons, and O or S, and is not > 2 double bonds. - 2. Non-toxic salts of (I). - (I) are long-acting hypoglycaemic agents.