| 摘要 |
<p>The present invention relates to the construction of a recombinant plasmid which is capable of expressing a secretory truncated glycoprotein (Tgp) of Varicella-zoster virus (BZV) in mammalian cells. The secretory Tgp of the present invention contains at least one epitope capable of inducing antibody response. the present invention comtemplates the production and utilization of this secretory Tgp in a vaccine against chickenpox and/or shingles. The present invention is also directed towards the use of the secretory Tgp in diagnostic assays for detection of VZV. The present invention is also directed to first antibodies specific to secretory Tgp and to second antibodies specific to the first antibodies. These second antibodies are also useful in diagnostic assays for VZV.</p> |
