| 摘要 |
<p>A hydrophilised solid surface having a biopolymer-repellent hydrophilic outer layer is produced by causing a solid surface with anionic groups capable of reacting with amino groups, to react with a polyethylene imine which is partly substituted by hydrophilic nonionic polymer chains having a molecular weight of 400-200,000. In this manner, it is possible to obtain a solid surface having a hydrophilic outer layer consisting of nonionic polymer chains which at one end are covalently bonded to a polyethylene imine which in turn is bonded to the solid surface via anionic groups capable of reacting with the amino groups in the polyethylene imine, the weight of the nonionic polymer chains being at least 50 % of the weight of the polyethylene imine. Such hydrophilised solid surfaces exhibit low spontaneous adsorption of biomolecules.</p> |
