4-AMINIO-DELTA 4,6-STEROIDS AND THEIR USE AS 5ALPHA-REDUCTASE INHIBITORS

摘要

The present invention relates to 4-amino- DELTA 4,6-steroids which are useful as inhibitors of 5 alpha -reductase. The compounds are prepared by the reaction of an appropriate 4,5-epoxy steroid with sodium azide in an inert solvent in the presence of a strong acid such as sulfuric acid at about 100 DEG C.