| 摘要 |
<p>NEW MATERIAL:The compound of formula I (R<1> is H or methyl; R<2> and R<3> are H, lower alkyl or R<2> and R<3> together with adjacent N form a heterocyclic group such as aziridinyl, azetidinyl, pyrrolidinyl and morpholino; A is single bond, lower alkylene, lower alkenylene or lower alkynylene). EXAMPLE:(5R,6S)-2-[(2S,5S)-2-dimethylcarbamoylpiperidin-5-yl]thio-6-[( 1R)-1- hydroxyethyl]-1-carbapen-2-em-3-carboxylic acid. USE:Medicine for microbism such as infectious diseases of respiratory organ and urinary tract, suppurative diseases and surgical infection disease. PREPARATION:A compound of formula II (R<5> is carboxyl-protecting group; Z is eliminable group) is made to react with a compound of formula III and the protective group of the product is removed.</p> |
