| 摘要 |
PURPOSE:To provide a platelet agglutination-inhibiting composition, containing a 1,5-benzothiazepin derivative and acetylsalicylic acid, exhibiting a remarkable synergistic activity and giving a high effect in a low dose. CONSTITUTION:The composition contains (A) a compound of the formula (R<1> is lower alkyl; R<2> is H, lower alkanoyl; R<3> is lover alkyl; R<4> is H, lower alkyl; R<5> is lower alkyl) or a salt thereof, e.g. (-)-cis-2-(4-methylphenyl)-3- acetoxy-5-[2-(dimethylamino)ethyl]-8-methyl-2,3-dihydro-1,5-benzothiaz epin-4(5)- one.maleate and (B) acetylsalicylic acid or a salt thereof in an A/B weight ratio of 1/0.1 to 1/40, preferably 1/0.3 to 1/10. The daily dose of the composition is preferably 10-100mg of A and 3-100mg of B within the range of the above- mentioned compounding ratio. |
