摘要 |
PURPOSE:To provide a platelet agglutination-inhibiting composition containing a 1,5-benzothiazepine derivative and acetylsalicylic acid, exhibiting a remarkable synergistic activity and giving a high effect in a low dose. CONSTITUTION:The composition contains (A) a compound of the formula (R<1> is lower alkyl; R<2> is H, lower alkanoyl; R<3>, R<4> are lower alkyl; X is halogen) or a salt thereof, e.g. (+)-cis-2-(4-methoxyphenyl)-3-acetoxy-5-[2-(dimethylamino) ethyl]-8-chloro-2,3-dihydro-1,5-benzothiazepin-4(5)-one.maleate and (B) acetylsalicylic acid or a salt thereof in an A/B weight ratio of 1/0.3 to 1/40, preferably 1/1 to 1/10. The daily dose of the composition is preferably 10-30mg of A and 30-100mg of B within the range of the above-mentioned ratio. |