1-(Tert.-butylamino)-3-((6-chloro-m-tolyl)-oxy)-2-propanol - for transdermal use to reduce total cholesterol content and for treatment of atherosclerosis

摘要

1-(tert. butylamino) -3-((-chloro m-tolyl)oxy)-2-propanol (I) can be used in a transdermal application form to reduce the concn. of total cholesterol in mammals. It also increases the concn. of high density lipoproteins, reduces the concn. of low density lipoproteins and reduces the concn. of triglycerides. USE/ADVANTAGE - (I) reduces blood lipid levels and can be used in transdermal application forms to treat atherosilerosis. (I) is a non-selective beta-receptor blocker without intrinsic sympathomimetic activity. In an example, a plaster was prepd. according to example 4 of EP0186019. The (I) plaster consisted of a matrix system consisting of a multilayered polyisobutylene contact film of total thickness 0.1mm which had been impregnated with the pharmaceutical. The outside was covered with a polyester foil. A plaster of 25 cm2 and 30 mg (I) in the form of the free base. The active surface was protected by a siliconised and metallised polyester foil which was removed before application