VERFAHREN ZUR HERSTELLUNG VON PEPTIDEN UNTER DER VERWENDUNG VON PERCHLORATEN.

摘要

The prepn. of a protected arginine -contg. peptide by fragment coupling comprises using at least one arginine contg. fragment as the perchlorate in each fragment coupling (B) A protected secretine deriv. of formula (I) is new R-His(R1)-Ser(but)-Asp (O But)-Gly-Thr(But)-Phe-Thr (but)-Ser(but-Glu(OBut)-Leu-Ser(But)-Arg(HClO4)-Leu-Arg(HClO4)-As- p(OBut-Ser(But)-Ala-Arg(HClO4)-Leu-Gln-Arg(HClO4)-Leu-Leu-Gln-Gly- -Leu-Val-NH2 (I) R and R1 = Boc or R = Boc and R1 = H or R and R1 = adamantyloxy carbonyl. But = tert butyl.