| 摘要 |
2-Cyclohexylacetylcyclohexanone, 2-cyclohexylacetylcyclopentanone, and 2-(3-cyclohexylpropanoyl)cyclopentanone are prepared by heating in an acidic aqueous medium 2-cyclohexylacetyl-1-BN-cyclohexene, 2-cyclohexylacetyl-1-BN-cyclopentene and 2-(3-cyclohexylpropanoyl)-1-BN-cyclopentene, respectively, where BN is morpholino, piperidino, pyrrolidino or di-(lower-alkyl)amino. These compounds are intermediates for the preparation of 2-hydroxy-3-(8-cyclohexyloctyl)-1,4-naphthoquinone and 2-hydroxy-3-(7-cyclohexylheptyl)-1,4-naphthoquinone, which are potent antimalarial agents.
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