发明名称 |
Camptothecin analogs as potent inhibitors of topoisomerase I |
摘要 |
A method for synthesizing camptothecin and camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase I and show anti-leukemic and anti-tumor activity.
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申请公布号 |
US5106742(A) |
申请公布日期 |
1992.04.21 |
申请号 |
US19890424910 |
申请日期 |
1989.10.23 |
申请人 |
WALL, MONROE E.;WANI, MANSUKH |
发明人 |
WALL, MONROE E.;WANI, MANSUKH |
分类号 |
A61K31/47;C07D471/04;C07D491/14;C07D491/20;C07D491/22 |
主分类号 |
A61K31/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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