| 摘要 |
The invention relates to a process for fixing an electrophilic group in the 2-position of 1H-pyrrolo¢3,2-c! pyridine N-protected in the 1-position. This process consists in protecting the 1-position of the derivative with a labile protecting group, reacting the compound lo obtained with a lithiation agent selected from a lithium amide and an alkyl lithium at a temperature between -80.degree.C and -20.degree.C and in the presence of tetramethylethylenediamine to obtain the corresponding 2-lithio derivative and then condensing the metal derivative so obtained at a temperature between -80.degree.C and room-temperature with a reagent capable of giving rise to an electrophilic group to form N-protected 1Hpyrrolo¢3,2c!pyridine substituted in the 2-position by an electrophilic group. The derivatives that are so obtained are useful as intermediate products, particularly for the preparation of biologically active compounds, especially anthelmintic compounds. |
