| 发明名称 |
HYDROXYQUINOLONE DERIVATIVES |
| 摘要 |
T1083 HYDROXYQUINOLONE DERIVATIVES A class of 4-hydroxy-2-(1H)-quinolone derivatives, substituted at the 3-position by an optionally substituted aryl substituent, are selective non-competitive antagonists of NMDA receptors and/or are antagonists of AMPA receptors, and are therefore of utility in the treatment of conditions, such as neurodegenerative disorders, convulsions or schizophrenia, which require the administration of an NMDA and/or AMPA receptor antagonist.
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| 申请公布号 |
CA2053465(A1) |
申请公布日期 |
1992.04.20 |
| 申请号 |
CA19912053465 |
申请日期 |
1991.10.15 |
| 申请人 |
MERCK SHARP & DOHME LIMITED |
发明人 |
KULAGOWSKI, JANUSZ J.;LEESON, PAUL D.;MAWER, IAN M.;ROWLEY, M. |
| 分类号 |
A61K31/47;A61K31/535;A61P1/08;A61P25/08;A61P25/28;A61P25/30;C07D215/22;C07D401/10;C07D401/12;C07D403/10;C07D405/04;C07D405/10;C07D405/12;C07D409/10;C07D409/12;(IPC1-7):C07D215/22;C07D401/02;C07D405/02;C07D409/02;C07D413/02 |
主分类号 |
A61K31/47 |
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