METHOD OF MAKING OIL FILLED PAUCILAMELLAR LIPID VESICLES

摘要

A new "cold-loading" technique for filling the amorphous central cavity of paucilamellar lipid vesicles with a water immis- cible material has been developed. Preformed, substantially aqueous filled paucilamellar lipid vesicles are mixed with the water immiscible material to be encapsulated under intermediate mixing conditions, thereby replacing the aqueous solution with the water-immiscible solution. The "cold-loading" technique is particulary usefu l for encapsulation of volatiles and heat labile mate- rials.