VERFAHREN ZUR STERILISATION VON PLASMA ODER PLASMAFRAKTIONEN.

摘要

The sterilisation of plasma or plasma fractions, including those factors which contain the blood coagulation factor VIII comprises treating the plasma with tri-n-butyl phosphate and sodium cholate or tween 80 either prior to or simultaneous with with the treatment of the plasma with B-pripiolactone or UV irradiation. Pref. sterilisation is carried out at +4 to 37 deg.C (esp. 23 deg.C), at pH 4.5-8.3 (esp. 7.2). Pref. the tri-n-butylphosphate is used in a concn. of 0.05-0.5% (esp. 0.3%) and the sodium chlolate in a concn. of 0.03-0.4% (esp. 0.2%). Alternatively pref. tri-n-butylphosphate is used in a concn. of 0.3% and the tween 80 in a concn. of 0.15-2%. Pref. the B-butyrolactone is used in a concn of 0.01-0,25% (pref. 0.05%). Pref. the UV light used is 254 nm.