INHIBITING UNWANTED IMMUNE RESPONSES

摘要

A hybrid protein including protein fragments joined together by covalent bonds, the protein fragments including: a fragment including a portion of IL-2, the portion including at least a portion of the binding domain of IL-2, the portion of the binding domain being effective to cause the hybrid protein to bind selectively to cells bearing the IL-2 receptor; and, an enzymatically inactive fragment of diphtheria toxin which does not include a functional diphtheria toxin generalized eukaryotic binding site. The hybrid protein capable of stimulating the proliferation of PBMC in vivo and of suppressing an immune response in a mammal in vivo.