Imidazole derivatives, potent and selective antagonists of angiotensin II receptor.

摘要

A compound of the formula : wherein R<1> is hydrogen, halogen, nitro, lower alkyl, lower alkoxy, amino or acylamino, R<2>, R<3> and R<4> are each hydrogen, halogen, nitro, cyano, lower alkyl, lower alkenyl, lower alkylthio, more or di or trihalo(lower)alkyl, oxo(lower)alkyl, hydroxy(lower)alkyl or optionally esterified carboxy; or R<2> and R<3> are linked together to form l,3-butadienylene, R<5> is hydrogen or imino-protective group, A is lower alkylene, Q is CH or N, X is N or CH, Y is NH, O or S, and is condensed or uncondensed imidazolyl which may have suitable substituent(s), and pharmaceutically acceptable salt thereof; processes for their preparation and pharmaceutical compositions comprising them.