| 摘要 |
NEW MATERIAL:A compound shown by formula I [R<1> to R<3> are H, alkyl, acyl, etc.; R<4> is (protected) amino; R<5> is H or ester residue or carboxy-protecting group; X is H, halogeno, alkyl, etc.] or a salt thereof. EXAMPLE:(Z)-2-(2-Aminothiazol-4-yl)-2-(3,4,5- trimethoxyethoxymethoxybenzyloxyimino)acetic acid. USE:An antimicrobial agent. PREPARATION:First, a compound shown by formula II is reacted with a compound shown by formula III in the presence of a condensation agent N,N'- dichlorohexylcarbodiimide in a solvent such as THF at -50 to 30 deg.C and acylated. Then, the prepared compound shown by formula IV is reacted and alkylated with a compound shown by the formula R<6>OH (R<6> is group shown by formula V) in a solvent such as THF in the presence of a base such as pyridine generally at -30 to 100 deg.C. |
