| 摘要 |
NEW MATERIAL:A compound shown by formula I (R<1> is H or OR<6>; R<2>, R<3> and R<6> are alkyl, acyl, etc.; R<4> is H, alkyl, etc.; R<5> is H, ester residue, etc.; X is H, halogen, etc.) or a salt thereof. EXAMPLE:3-[[2-(Diphenylmethoxycarbonyl)-5-methyl-[1,2,4]triazo-[1,5- a]pyrimidin-7-yl]thiomethyl]-7beta[(Z)-2-methxovimino-2-(3, 4-O- isopropylidenedioxyphenyl)acetamido]-3-cephem-4-carboxylic acid diphenyl methyl. USE:An antitumor agent. PREPARATION:First, a compound shown by formula II is reacted with a compound shown by formula III in the presence of a condensation agent such as N,N'-dichlorocarbodiimide in a solvent such as THF and acylated. Then, the formed compound shown by formula IV is reacted with a compound shown by formula R<4>OH in the presence of a base such as pyridine in a solvent such as THF and alkylated. |
