发明名称 VERFAHREN ZUR HERSTELLUNG VON PENEM-VERBINDUNGEN
摘要 <p>There is provided a process for the preparation of compounds of formula (I) useful as antibacterials: <CHEM> wherein R represents hydrogen atom or a hydroxy protecting group, which process comprises reacting a compound of formula (II) <CHEM> wherein R is as defined above, with an oxalyl halide in an inert solvent; optionally converting the resultant compound of the formula III <CHEM> wherein R is as defined above and X is a halogen atom into a compound of the formula III in which X represents a hydroxy group by hydrolysis; either (i) treating the compound of formula III in which X is a halogen atom with a compound of the formula IV <CHEM> wherein Y is a hydroxy group in the presence of an acid scavenger or an organic or inorganic base or (ii) treating the compound of the formula III in which X is a hydroxy group, with a compound of the formula IV in which Y is a leaving group in the presence of a base; cyclizing the resultant compound of the formula V <CHEM> wherein R is as defined above and optionally deprotecting the resultant compound of the formula I wherein R is a hydroxy protecting group to obtain a compound of the formula I wherein R is a hydrogen atom.</p>
申请公布号 DD299304(A5) 申请公布日期 1992.04.09
申请号 DD19900344385 申请日期 1990.10.02
申请人 FARMITALIA CARLO ERBA S.R.L.,IT 发明人 PERRONE,ETTORE,;ALPEGIANI,MARCO,;ZARINI,FRANCO,;MAZZINI,GIUSEPPE,;FRANCESCHI,GIOVANNI,
分类号 A61K31/43;A61K31/431;A61P31/04;C07D;C07D317/40;C07D499/06;C07D499/88;C07D499/883;C07D499/897;(IPC1-7):C07D499/88 主分类号 A61K31/43
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