| 摘要 |
<p>PURPOSE:To obtain the title intermediate for a raw material of producing a carbapenem compound useful as an antimicrobial agent by reacting a specific azetidinone compound with an aldehyde compound and then with a triarylphosphine. CONSTITUTION:An azetidinone compound (salt) shown by formula I [R<2> is hydroxy (lower) alkyl., etc.; R<3> is H or lower alkyl; R<4> is halo (lower) alkyl; R<5> is H or imino-protecting group; A is lower alkylene] is made to react with an aldehyde compound shown by CHO-R<1> [R<1> is (protected) carboxyl] or a reactive equivalent thereof to give a compound (salt) shown by formula II. Then, this compound is halogenated to give a compound (salt) shown by formula III (X is halogen), which is reacted with a triarylphosphine shown by the formula P(R<6>)3 (R<6> is aryl) to give the objective carbapenem intermediate shown by the formula IV.</p> |
