PEPTIDE DERIVATIVES.

摘要

A peptide having a peptide sequence of formula (I) and containing 25 to 50 amino acid residues in total, its amide and salts thereof (I): Leu-Met-His-Asn-Leu-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Phe-Phe-Le u-His-His-Leu-Ile-Ala-Glu-Ile. These peptide derivatives exhibit a potent inhibitory activity against hPTH superior to that of conventional ones and are expected to be useful for treating metabolic diseases wherein calcium or phosphoric acid participates, such as hypercalcemia and osteoporosis, or diseases wherein PTH and PTHrP participate.