Certain 3,3'-[[[(2-phenyl-4-thiazolyl)methoxy]phenyl]methylene]dithiobis-propanoic acid derivatives

摘要

There are disclosed compounds of the formula <IMAGE> wherein X is <IMAGE> Y is <IMAGE> Z is -(CH2)nO-, -(CH2)nS-, <IMAGE> <IMAGE> R1 is <IMAGE> <IMAGE> <IMAGE> <IMAGE> n is 0-5; R2 is hydrogen, loweralkyl, loweralkoxy, lower alkoxycarbonyl, trifluoromethyl, nitro, cyano or halo; R3 is <IMAGE> W represents a bond or -O-, -S- or <IMAGE> m is 1-15; R4 is hydrogen or loweralkyl; R5 is lower alkyl, monofluoroloweralkyl, difluroloweralkyl, polyfluroloweralkyl, perfluoroloweralkyl or <IMAGE> R6 is hydrogen lower alkyl, -COOR4 or <IMAGE> R7 is OR4 or N(R4)2; R8 is OR4 or N(R4)2; and the pharmaceutically acceptable salts thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstruction airpassageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like, as antiinflammatory agents.