发明名称 |
Trans-6-(2-(n-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl- or ethenyl)tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis |
摘要 |
Certain trans-6-[2-(N-heteroaryl-3,5-disubstituted) pyrazol-4-yl)ethyl]- or ethenyl]tetrahydro-4-hydroxy-2H-pyran-2-ones and the corresponding ring-opened acids, esters and N-oxides derived therefrom which are potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG CoA reductase) and are thus useful hydrolipidemic or hypocholesterolemic agents. Pharmaceutical compositions containing such compounds, and a method of inhibiting the biosynthesis of cholesterol employing such pharmaceutical compositions are also disclosed.
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申请公布号 |
US5102893(A) |
申请公布日期 |
1992.04.07 |
申请号 |
US19900540047 |
申请日期 |
1990.06.19 |
申请人 |
WARNER-LAMBERT COMPANY |
发明人 |
PICARD, JOSEPH A.;ROTH, BRUCE D.;SLISKOVIC, DRAGO R. |
分类号 |
C07D405/14;C07D409/14;C07D417/14 |
主分类号 |
C07D405/14 |
代理机构 |
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代理人 |
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地址 |
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